Even in that case you should consider that your readers might have a diverse range of devices, and configuring a 1000:1 contrast ratio isn't exactly the greatest solution.

Keep colors and contrast restricted to the range possible by reflective materials (i.e. what can be printed on paper or ever be encountered in nature) and all the issues are immediately gone. You don't have to use grey-on-grey (which is super annoying). Just keep to the range of colors a newspaper will have, or a zebra will have.